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【Bangkok, Tha】[IMCAS Asia 2026 Special ⑬ | Interview] The First 2–3 Days After Laser Treatment Are the ‘Golden Period’ — Dr. Santi Jaturawichanant, P198 KOL

Jul 17, 2026

Editor’s Note

**Editor’s Note:** This article explores a novel approach to enhancing topical exosome delivery through laser-created microchannels, addressing the barrier posed by the stratum corneum. Dr. Santi Jaturawichanant’s technique offers a potential alternative to injection-based methods, with implications for efficacy and safety in aesthetic dermatology.

Laser-created microchannels for deeper topical delivery of an exosome preparation

Topical, non-injection EV formulations versus polymer boosters amid granuloma concerns
Topical application of exosome preparations faces a recognized limitation: the intact stratum corneum can restrict transcutaneous delivery. Dr. Santi Jaturawichanant, MSc in Dermatology, of B’est Clinic in Bangkok, addresses this limitation through laser pretreatment. By creating fine microchannels across the epidermis and into the superficial dermis, he seeks to facilitate deeper and more efficient topical delivery of the exosome preparation. The concept he returns to is the “golden period” — in his clinical practice, he regards the first two to three days after treatment as the interval during which he believes the laser-created channels have not yet fully closed and topical delivery remains most favorable. His protocol is built around capturing it.
A KOL for Primoris International’s P198 exosome skin booster line, Dr. Santi spoke at the PRISM in IMCAS Asia 2026 dinner symposium on June 19 and subsequently delivered a live patient demonstration, “Synergistic Exosome Therapy with Laser on Face,” in the official IMCAS scientific program. We sat down with him to discuss his clinical use of laser–exosome combination protocols for concerns including enlarged pores, wrinkles, and acne scarring, as well as their potential effects on skin quality and hydration, and his perspective on how Korean medical aesthetics is being received in Thailand and the broader Southeast Asian market.

Q. Could you briefly introduce yourself and share your impressions of IMCAS Asia 2026? As this year’s edition is being held here in Bangkok, is there anything that makes it feel particularly special?

“I am Dr. Santi Jaturawichanant, from B’est Clinic here in Bangkok. Having IMCAS Asia organized in our own city this year makes it especially meaningful — we are able to welcome colleagues from around the world to our home ground.”

IMCAS Asia has now been running for more than a decade. A wide range of trends in aesthetic medicine, longevity, and wellness are emerging from Asia, and physicians from Western countries also attend the congress.

Q. You delivered a live patient demonstration at IMCAS Asia 2026 on the topic of “Synergistic Exosome Therapy with Laser on Face.” What was the clinical rationale behind this topic, and what was the key message you wanted to convey?

There is already evidence suggesting that stem cell-derived exosomes, a type of extracellular vesicle, can be absorbed through the skin when applied topically. So topical application alone does have an effect.

“The core of my presentation, however, was the deliberate use of laser prior to exosome application to create small microchannels across the epidermis and into the upper dermis. This makes penetration easier, faster, and more efficient. In my experience, this improves skin quality more than either laser treatment alone or exosome application alone.”

Q. How do you incorporate the P198 exosome line into your day-to-day practice? Which skin concerns do you address most frequently, and what changes have you observed?

The patient population at an aesthetic medicine clinic like mine is predominantly concerned with the appearance of the skin. Enlarged pores, wrinkles, and acne scars are among the most common concerns I see.

“These are precisely the areas in which I most often incorporate an exosome booster. I use it to support improvements in skin quality and hydration, as well as in the appearance of acne scars.”

Q. Compared with polymer-based skin boosters, what do you see as the key clinical advantages of extracellular vesicle-based products such as P198 FILCORE SB PLUS?

Polymer-based skin boosters carry a clinical consideration worth noting: when polymer particles cluster or accumulate at an injection site, they may contribute to granuloma or nodule formation.

“In my clinical experience, topical extracellular vesicle-based formulations do not present the same granuloma concerns associated with some injectable polymer products. They can also help fatigued or less-active skin cells become more active and healthier. That, in my view, is what sets them apart.”

Q. When combining P198 with laser or energy-based devices, what protocol insights have you developed around the timing and frequency of application?

My protocol calls for immediate post-procedure exosome application — as soon as the laser session is complete. I then provide the patient with product for home use, with instructions to reapply over the following two to three days.

“In practice, this amounts to approximately five applications in total. That two-to-three-day period is what I refer to as the golden period. I regard it as the interval before the laser-created microchannels have fully closed, when topical absorption of the exosome preparation is most favorable. Once the channels have closed, that enhanced delivery opportunity is lost. The entire protocol is designed to make full use of it.”

In my experience, almost every patient I have treated with P198 has been satisfied with the outcome.
One case in particular remains with me. A patient presented with an allergic skin reaction and visible lesions. We were able to compare an area where the exosome preparation had been applied with an area that did not receive the preparation. The treated area appeared to improve more quickly, with inflammation subsiding sooner. It was a memorable side-by-side observation for me.

Q. How do you account for the growing interest in exosome-based products in aesthetic medicine?

“Nowadays, everyone wants healthy-looking skin and a general sense of vitality and well-being. So everyone is looking for ways to reduce inflammation and get the best possible result from their treatment.”

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⏰ Published on: July 17, 2026